21st Century Center of Excellence (COE) Program Graduate School of Medicine, Keio University
Establishment of Individualized Cancer Therapy Based on Comprehensive
Development of Minimally Invasive and Innovative Therapeutic MethodsJapanese Site
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Program member
Program member
Daisuke Aoki
Daisuke Aoki
Affiliation Professor,
Department of Obstetrics and Gynecology, Graduate School of Medicine,
Keio University
  Research activities in the COE program
  Development of new molecular biology-based diagnostic and therapeutic methods for gynecological cancers

Our research aims to develop new diagnostic and thrapeutic methods for gynecological cancers based upon an understanding of the underlying cell biology and elucidation of carcinogenesis-related molecules. One research aspect of our research focuses on development of human monoclonal antibodies targeting gynecological cancers (Figs. 1, 2); these antibodies show great clinical potential based upon their high specificity. Another aspect focuses on the development of anti-viral drugs that ruin the function of E2 or E7 proteins of the human papilloma virus, a virus strongly involved in the carcinogenesis of cervical cancer. The final aspect focuses on familial endometrial cancers and associated germ-line mutations in mismatch repair enzyme genes (hMSH2, hMLH1, hMSH6, etc.).

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