21st Century Center of Excellence (COE) Program Graduate School of Medicine, Keio University
Establishment of Individualized Cancer Therapy Based on Comprehensive
Development of Minimally Invasive and Innovative Therapeutic MethodsJapanese Site
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Program member
Program member
Atsushi Kubo
Atsushi Kubo
Affiliation Professor,
Department of Radiology,
Graduate School of Medicine,
Keio University
  Research activities in the COE program
  Molecular imaging

Our project is to develop non-invasive in vivo molecular imaging, especially using radionuclides. From the point of view of sensitivity, nuclear medicine has a great advantage over other areas. Making full use of this advantage, we have already achieved molecular imaging of the following:
  1. The P-glycoprotein, one of the multi-drug-resistance-related proteins, using Tc-99m-labeled MIBI, a substance of P-glycoprotein. This enabled us to monitor the tumor and observe whether it was resistant to anti-cancer drugs both before and after chemotherapy.
  2. A hypoxic area or the oxygen state using Tc-99m-labeled HL91. This enabled us to select a tumor and observe whether it was sensitive to radiotherapy since hypoxic tumors are resistant to radiation.
  3. Sentinel nodes, using our special preparation of Tc-99m-labeled colloids. This enabled us to detect the sentinel nodes of a variety of tumors using radiolabeled colloids, with different sizes for each tumor.
  4. The multi-drug-resistance (mdr)-1 gene using Tc-99m-labeled antisense to mdr-1. Following the development of antisense imaging, the world's first image was reported (Figure). This technique is applicable to any mRNA as long as it is overexpressed in cells.
We are currently conducting the following experiments based on what we found above:
  1. The development of specific radiopharmaceuticals in order to obtain clear gene imaging
  2. The development of gene imaging of mRNA that is overexpressed after radiation therapy
  3. The development of a special imaging device for whole body of small animals
  4. The development of fusion software in order to obtain more precise molecular imaging

The goal of our project is to develop non-invasive molecular imaging, primarily for genes, in order to provide information for the tailor-made management of cancer patients.
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