21st Century Center of Excellence (COE) Program Graduate School of Medicine, Keio University
Establishment of Individualized Cancer Therapy Based on Comprehensive
Development of Minimally Invasive and Innovative Therapeutic MethodsJapanese Site
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Program member
Program member
Tetsuro Kubota
Tetsuro Kubota
Affiliation Associate Professor,
Department of Surgery, Graduate School of Medicine,
Keio University
  Research activities in the COE program
  Molecular approach to cancer chemosensitivity

We have been investigating the chemosensitivity test, which is useful in evaluating the appropriate adjuvant cancer chemotherapy for advanced gastrointestinal carcinomas. It was repeatedly confirmed that the sensitive group had a favorable survival outcome compared with the resistant group. We have been also investigating the molecular biological chemosensitivity test using microarrays and RT-PCR. Dihydropyrimidine dehydrogenase expression, which is a rate-limiting catabolizing enzyme of 5-FU, has been repeatedly determined to be the resistance-related gene to 5-FU. Our present interest is to overcome tumor chemoresistance by targeting the resistance-causal genes.
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