21st Century Center of Excellence (COE) Program Graduate School of Medicine, Keio University
Establishment of Individualized Cancer Therapy Based on Comprehensive
Development of Minimally Invasive and Innovative Therapeutic MethodsJapanese Site
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Program member
Program member
Michiie Sakamoto
Michiie Sakamoto
Affiliation Professor,
Department of Pathology, Graduate School of Medicine,
Keio University
  Research activities in the COE program
  Comprehensive analysis of molecules involved in cancer progression and their clinical application

Pathological diagnosis plays a critical role in cancer diagnosis and treatment. In order to establish individualized cancer therapy, a more detailed pathological diagnosis including molecular diagnosis is expected. Our research group has conducted molecular pathological research based on the original concept raised through detailed pathological examination of a variety of human cancers. In this program, we perform fruitful translational research through the following projects.
(1) Integrated transcriptomics/proteomics and pathology research: identification of cancer related genes, tumor markers and molecular targets for therapy; elucidation of cell-cell and intermolecular interaction and signaling regulating cancer pathobiology; establishment of scFv antibodies and human monoclonal antibodies.
(2) Molecular biological analysis of cancer progression and metastasis utilizing human cancer model in immunodeficient mice: establishment of orthotopic models of human cancer reproducing clinicopathological pictures of the cancer; functional analysis of identified molecules in vivo; preclinical trial of targeted therapy; reconstitution of cancer stroma, analysis of cancer-stroma interaction and establishment of innovative cell therapy.
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